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Genes (352)
Species: human : 352 | |
Human | AD10 | 780912 | Alzheimer disease-10 | Presenile and senile dementia | Human | LOC646506 | 646506 | lysosomal-associated membrane protein 1 pseudogene | immunohistochemical studies have shown increased LAMP-1 immunoreactivity in neurones, and in glial cells surrounding senile plaques, in Alzheimer's disease cases | Human | LOC643387 | 643387 | TAR DNA binding protein pseudogene | TDP-43-positive inclusions within neurons and oligodendroglia were found in brains from patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) TDP-43 immunoreactivity in Alzheimer's disease was associated with granular and filamentous cytosolic material | Human | AD9 | 450086 | Alzheimer disease 9 | Presenile and senile dementia | Human | MIR146A | 406938 | microRNA 146a | NF-kappaB-sensitive miRNA-146a-mediated modulation of complement factor H gene expression may in part regulate an inflammatory response in Alzheimer disease brain | Human | ARMS2 | 387715 | age-related maculopathy susceptibility 2 | The LOC387715/ARMS2 gene is expressed in the human brain, and it may concur to the individual risk for Alzheimer's disease | Human | AGRN | 375790 | agrin | evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer's disease is accumulating--REVIEW | Human | AD8 | 353128 | Alzheimer disease 8 | Presenile and senile dementia | Human | LRRTM3 | 347731 | leucine rich repeat transmembrane neuronal 3 | Data suggest that LRRTM3 is a functional and positional candidate gene for Alzheimer disease, and, given its receptor-like structure and restricted expression, a potential therapeutic target | Human | SREK1IP1 | 285672 | SREK1-interacting protein 1 | p18SRP is a lysine-rich zinc finger domain-containing protein that interacts with the serine-arginine-rich splicing regulatory protein SRrp86; it is downregulated in brain of Alzheimer disease patients | Human | LAMA1 | 284217 | laminin, alpha 1 | Alpha 1 laminin was heavily over-expressed in Alzheimer disease frontal cortex, and localized in reactive astrocytes of the grey and white matter, and as punctate deposits in the senile placques of the Alzheimer brain tissue | Human | PCSK9 | 255738 | proprotein convertase subtilisin/kexin type 9 | Genetic polymorphisms are not associated with Alzheimer disease and cholesterol in Japanese patients | Human | CALHM1 | 255022 | calcium homeostasis modulator 1 | Study determined that the CALHM1 P86L polymorphism is associated with Alzheimer's disease, further found that the P86L polymorphism increases amyloid-beta levels by interfering with CALHM1-mediated Ca(2+) permeability Study assessed the potential association between Alzheimer's Disease risk and the Pro86Leu variant in the CALHM1 gene; no association was observed, either in the individual samples or in the combined analyses of more than 8100 subjects Protein may be a genetic determinant of Alzheimer disease, since a polymorphism reduces calcium permeability | Human | STH | 246744 | saitohin | Increased risk of Alzheimer's disease associated with the STH RR genotype is limited to late-onset Alzheimer's disease The R allele of STH is associated with the H2 haplotype of tau; no correlation is found between R allele frequency and Alzheimer's or Parkinson's disease | Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Loss of specific miRNAs can contribute to increased BACE1 and Abeta levels in sporadic Alzheimer's disease.[miR-29a, miR-29b1] | Human | LRRC15 | 131578 | leucine rich repeat containing 15 | Lib may contribute to regulation of cell-matrix adhesion interactions with respect to astrocyte recruitment around senile plaques in Alzheimer's disease brain | Human | LRRK2 | 120892 | leucine-rich repeat kinase 2 | we did not detect the G2019S mutation in any of 769 Italian Alzheimer disease patients We screened for the most common LRRK 2 mutation in a series of patients with Parkinson's Disease, Alzheimer's disease, Progressive Supranuclear Palsy, Multiple System Atrophy and frontotemporal dementia, as well as in neurologically normal controls | Human | COL25A1 | 84570 | collagen, type XXV, alpha 1 | suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth | Human | RNF146 | 81847 | ring finger protein 146 | Dactylidin may function early in the progression of Alzheimer's disease | Human | BHLHB9 | 80823 | basic helix-loop-helix domain containing, class B, 9 | Down-regulation in the brain of Alzheimer's disease subjects point to a possible pivotal role of p60TRP in the control of cellular aging and survival | Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | Aberrant neuronal and paracellular deposition of endostatin in brains of patients with Alzheimer's disease Collagen XVIII is a heparan sulfate proteoglycan associated with vascular amyloid beta and senile plaques in Alzheimer Disease | Human | PTGES2 | 80142 | prostaglandin E synthase 2 | microsomal prostaglandin-E synthase is normally expressed constitutively in human neurons, microglia, astrocytes, and endothelial cells but is up-regulated in Alzheimer's disease | Human | RTN4R | 65078 | reticulon 4 receptor | results showed that NgR immunoreactivity was present in more than 50% of the pyramidal layer cells of the CA1 to CA4 subfields of the hippocampus; results suggest that NgR may be related to the formation of tangles in Alzheimer's disease The molecular requirements for cerebral amyloid-beta peptide interaction with NgR are defined and correlated with the affinity of these polypeptides to improve spatial memory impairments in Alzheimer disease model mice | Human | AD6 | 64851 | Alzheimer disease 6 | Presenile and senile dementia | Human | ABCG4 | 64137 | ATP-binding cassette, sub-family G (WHITE), member 4 | ABCG4 is highly expressed in microglia on alzheimer disease brain |
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