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Details
Link-It Detail - Disease - Alcoholism
Debug Stats
  • ### Total Build Time: 117 ms 55.927 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 318 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.211 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 201 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 561 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=2 ms Completed: 2 ms rowSize= 1.516 KB
  • CONCEPT_RELATIONSHIPS gt=82 ms Completed: 82 ms rowSize= 14.250 KB
  • CONCEPT_GENES gt=25 ms Completed: 25 ms rowSize= 36.716 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.145 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Alcoholism C0001973
Definition (1)

For most adults, moderate alcohol use is not harmful. However, nearly 17.6 million adults in the United States are alcoholics or have alcohol problems. Alcoholism is a disease with four main features:

  • Craving - a strong need to drink
  • Loss of control - not being able to stop drinking once you've begun
  • Physical dependence - withdrawal symptoms, such as nausea, sweating or shakiness after stopping drinking
  • Tolerance - the need to drink greater amounts of alcohol in order to get "high"

Alcoholism carries many serious dangers. Heavy drinking can increase the risk of certain cancers. It can cause damage to the liver, brain and other organs. It can cause birth defects. It increases the risk of death from car crashes and other injuries as well as the risk of homicide and suicide.

NIH: National Institute on Alcohol Abuse and Alcoholism

Semantic Types (1)
Mental or Behavioral Dysfunction (T048)
Parents (1)
img Alcohol-Related Disorders C0236664
Ancestral Roots
RootRoot Plus OneDepthParent
img Mental Disorders C0004936img Substance-Related Disorders C02369694img Alcohol-Related Disorders C0236664
Relationships (216)

Relation Types:
diso_​to_​anat : 14
diso_​to_​chem : 80
diso_​to_​diso : 89
diso_​to_​gene : 3
diso_​to_​phen : 5
diso_​to_​phys : 25


Relationships:
none : 172
associated_​with : 1
isa : 3
mapped_​to : 2
may_​treat : 33
related_​to : 4
use : 1
Page Size
Current 25
  Page 1 of 9
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO934img Complication Aspects C1171258
DISO_to_DISO735img Complication Aspects C1171258
DISO_to_PHEN715img genetic aspects C0017399
DISO_to_PHEN680img genetic aspects C0017399
DISO_to_DISO637img Substance-Related Disorders C0236969
DISO_to_DISO441img AODR disorder C0236969
DISO_to_CHEM346img Ethanol C0001962
DISO_to_CHEM316img Ethanol C0001962
DISO_to_ANAT287img In Blood C0005768
DISO_to_ANAT218img In Blood C0005768
DISO_to_DISO153img AOD withdrawal syndrome C0038587
DISO_to_DISO148img Mental Disorders C0004936
DISO_to_CHEM144img Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)- C0027360
DISO_to_CHEM144img Naltrexone C0027360
DISO_to_ANAT143img Brain C0006104
DISO_to_ANAT139img Brain C0006104
DISO_to_CHEM136img Alcohol Deterrents C0001947
DISO_to_CHEM132img Alcohol Deterrents C0001947
DISO_to_DISO124img Mental Disorders C0004936
DISO_to_CHEM115img Drugs, Street C0038388
DISO_to_PHYS115img Motivation C0026605
DISO_to_CHEM111img Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)- C0027360
DISO_to_CHEM100img Narcotic Antagonists C0027410
DISO_to_DISO97img Depression C0011570
DISO_to_PHYS97img GENET PREDISPOSITION C0314657
Genes (90)

Species:
human : 90
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanZNF699374879zinc finger protein 699
img GENERIF, Score=1000, Pubmed Id: 16940975, UMLKSK CUI: C0001973
HumanANKK1255239ankyrin repeat and kinase domain containing 1
img GENERIF, Score=1000, Pubmed Id: 15545020, UMLKSK CUI: C0001973
img GENERIF, Score=1000, Pubmed Id: 17761687, UMLKSK CUI: C0001973
img GENERIF, Score=1000, Pubmed Id: 17453061, UMLKSK CUI: C0001973
img GENERIF, Score=1000, Pubmed Id: 17850642, UMLKSK CUI: C0001973
HumanTPH2121278tryptophan hydroxylase 2
img GENERIF, Score=1000, Pubmed Id: 17251907, UMLKSK CUI: C0001973
HumanACN957001ACN9 homolog (S. cerevisiae)
img GENERIF, Score=1000, Pubmed Id: 18163977, UMLKSK CUI: C0001973
HumanTTC1254970tetratricopeptide repeat domain 12
img GENERIF, Score=1000, Pubmed Id: 17761687, UMLKSK CUI: C0001973
HumanGAL51083galanin/GMAP prepropeptide
img GENERIF, Score=1000, Pubmed Id: 16314872, UMLKSK CUI: C0001973
HumanTAS2R1650833taste receptor, type 2, member 16
img GENERIF, Score=1000, Pubmed Id: 16385453, UMLKSK CUI: C0001973
HumanKCNMB427345potassium large conductance calcium-activated channel, subfamily M, beta member 4
img GENERIF, Score=1000, Pubmed Id: 18981408, UMLKSK CUI: C0001973
HumanMGLL11343monoglyceride lipase
img GENERIF, Score=1000, Pubmed Id: 17621164, UMLKSK CUI: C0001973
HumanSIGMAR110280sigma non-opioid intracellular receptor 1
img GAD, Score=1000, Pubmed Id: 14706429, UMLKSK CUI: C0001973
HumanCARTPT9607CART prepropeptide
img GENERIF, Score=1000, Pubmed Id: 15234472, UMLKSK CUI: C0001973
HumanNRXN39369neurexin 3
img GENERIF, Score=1000, Pubmed Id: 17804423, UMLKSK CUI: C0001973
HumanSGCE8910sarcoglycan, epsilon
img GENERIF, Score=1000, Pubmed Id: 17296918, UMLKSK CUI: C0001973
HumanGALR28811galanin receptor 2
img GENERIF, Score=694, Pubmed Id: 17083333, UMLKSK CUI: C0001973
HumanGALR38484galanin receptor 3
img GENERIF, Score=1000, Pubmed Id: 17083333, UMLKSK CUI: C0001973
HumanYWHAH7533tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
img GAD, Score=1000, Pubmed Id: 10776673, UMLKSK CUI: C0001973
HumanTPH17166tryptophan hydroxylase 1
img GAD, Score=1000, Pubmed Id: 16257348, UMLKSK CUI: C0001973
img GENERIF, Score=1000, Pubmed Id: 15654285, UMLKSK CUI: C0001973
HumanTH7054tyrosine hydroxylase
img GAD, Score=1000, Pubmed Id: 15722952, UMLKSK CUI: C0001973
HumanTF7018transferrin
img GENERIF, Score=1000, Pubmed Id: 17573378, UMLKSK CUI: C0001973
HumanTACR36870tachykinin receptor 3
img GENERIF, Score=1000, Pubmed Id: 18422838, UMLKSK CUI: C0001973
HumanSNCA6622synuclein, alpha (non A4 component of amyloid precursor)
img GENERIF, Score=1000, Pubmed Id: 15731118, UMLKSK CUI: C0001973
img GENERIF, Score=1000, Pubmed Id: 15671870, UMLKSK CUI: C0001973
HumanSLC22A16580solute carrier family 22 (organic cation transporter), member 1
img GAD, Score=1000, Pubmed Id: 15499200, UMLKSK CUI: C0001973
HumanSLC6A46532solute carrier family 6 (neurotransmitter transporter), member 4
Click here to display 20 evidence detail records.
HumanSLC6A36531solute carrier family 6 (neurotransmitter transporter), member 3
img GAD, Score=1000, Pubmed Id: 16125912, UMLKSK CUI: C0001973
img GENERIF, Score=1000, Pubmed Id: 11807408, UMLKSK CUI: C0001973
img GAD, Score=1000, Pubmed Id: 11244477, UMLKSK CUI: C0001973
img GAD, Score=1000, Pubmed Id: 10578237, UMLKSK CUI: C0001973
img GAD, Score=1000, Pubmed Id: 10088054, UMLKSK CUI: C0001973
img GAD, Score=1000, Pubmed Id: 11807408, UMLKSK CUI: C0001973
HumanSLC6A26530solute carrier family 6 (neurotransmitter transporter), member 2
img GENERIF, Score=1000, Pubmed Id: 17630229, UMLKSK CUI: C0001973
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0001973Alcoholism0self