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Genes (90)
Species: human : 90 | |
Human | ZNF699 | 374879 | zinc finger protein 699 | In analyses of genetically independent cases and controls, four of the seven single markers show strong evidence for association with alcohol dependence, and the most significant single marker, rs7254880, tags an associated haplotype with frequency 0.071 | Human | ANKK1 | 255239 | ankyrin repeat and kinase domain containing 1 | the TaqIA1 allele of the dopamine receptor gene D2 has been associated with alcoholism, as well as with other addictive behaviours association studies of alcohol dependence and 43 SNPs mapped to the gene cluster of NCAM1, TTC12, ANKK1 and DRD2 Results of this meta-analysis support the association of the DRD2 Taq1A polymorphism with alcoholism More extensive genotyping across DRD2 and ANKK1 suggests that the association with alcohol dependence observed in this region may be due to genetic variants in the ANKK1 gene | Human | TPH2 | 121278 | tryptophan hydroxylase 2 | Haplotypes of the TPH2 gene are unlikely to play a major role in the pathophysiology of alcohol dependence or the alcoholism-related phenotype suicidal behavior | Human | ACN9 | 57001 | ACN9 homolog (S. cerevisiae) | ACN9 is involved in the predisposition to alcohol dependence | Human | TTC12 | 54970 | tetratricopeptide repeat domain 12 | association studies of alcohol dependence and 43 SNPs mapped to the gene cluster of NCAM1, TTC12, ANKK1 and DRD2 | Human | GAL | 51083 | galanin/GMAP prepropeptide | There is a haplotype association with alcoholism in both the Finnish (P=0.001) and Plains Indian (P=0.004) men | Human | TAS2R16 | 50833 | taste receptor, type 2, member 16 | Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence, especially in African-Americans | Human | KCNMB4 | 27345 | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | The beta4 subunit controls ethanol tolerance at the molecular, cellular, and behavioral levels, and could determine individual differences in alcohol abuse and alcoholism, as well as represent a therapeutic target for alcoholism | Human | MGLL | 11343 | monoglyceride lipase | not associated with susceptibility to alcoholism in a Japanese population | Human | SIGMAR1 | 10280 | sigma non-opioid intracellular receptor 1 | Title:Functional polymorphisms in the sigma1 receptor gene associated with alcoholism.|Association:Y|Conclusion:The T-485A and the GC-241-240TT may be functional polymorphisms, and the A-485 allele and TT-241-240/Pro2 haplotype are possible protective factors for the development of alcoholism. | Human | CARTPT | 9607 | CART prepropeptide | AvaII polymorphism (rs2239670) in intron 1 of the CART gene is associated with alcoholism in the Korean male population | Human | NRXN3 | 9369 | neurexin 3 | details of NRXN3's gene structure and variants, and association of NRXN3 SNPs with alcohol dependence | Human | SGCE | 8910 | sarcoglycan, epsilon | Obsessive-compulsive disorder and alcohol dependence are associated with manifesting mutated SGCE | Human | GALR2 | 8811 | galanin receptor 2 | There was no effect of GALR2 on alcoholism risk | Human | GALR3 | 8484 | galanin receptor 3 | GALR3 showed a significant association with alcoholism that was driven by one SNP (rs3,091,367) | Human | YWHAH | 7533 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | Title:Association study between genetic polymorphisms in the 14-3-3 eta chain and dopamine D4 receptor genes and alcoholism.|Association:Not Found|Conclusion:YWHAH and DRD4 do not appear to play a major role in the development of alcoholism. | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Title:|Association:Y|Conclusion:Not Found Polymorphisms in the promoter region may influence the function of the TPH1 gene and further influence the proclivity of alcohol dependence in one ethnic group in Taiwan | Human | TH | 7054 | tyrosine hydroxylase | Title:Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism.|Association:Y|Conclusion:Our results suggest a role for tyrosine hydroxylase in early-onset alcoholism. | Human | TF | 7018 | transferrin | Serum level of sialic acid in patients with chronic alcohol abuse depends on the concentration of the most sialylated glycoproteins: alpha 1-antitrypsin, alpha 1-acid glycoprotein, and transferrin | Human | TACR3 | 6870 | tachykinin receptor 3 | small nucleotide polymorphisms in the 3' region of tachykinin receptor 3 gene (TACR3) provided significant evidence of association with alcohol dependence | Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | the NACP-REP1 marker within the alpha synuclein gene may be associated with alcohol dependence A significantly elevated gene-specific alpha synuclein promoter DNA methylation pattern is observed in peripheral mononuclear cells of patients with chronic alcoholism | Human | SLC22A1 | 6580 | solute carrier family 22 (organic cation transporter), member 1 | Title:Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1)|Association:Not Found|Conclusion: | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Click here to display 20 evidence detail records. | Human | SLC6A3 | 6531 | solute carrier family 6 (neurotransmitter transporter), member 3 | Title:Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism.|Association:Not Found|Conclusion: results suggest that both the DRD2 promoter region and the DAT gene do not play a significant role in conferring vulnerability to alcoholism (Dopamine Transporter DAT) Title:DRD4 and DAT1 as modifying genes in alcoholism:interaction with novelty seeking on level of alcohol consumption|Association:Not Found|Conclusion:The possible presence of an interaction effect between DRD4 and DAT1 gnotypes with novelty seeking on the level of consumption suggests that these genotypes may increase the alcohol-seeking behavior in high novelty seeking individuals, supporting that model. Title:|Association:Not Found|Conclusion:Not Found Title:DAT1 gene polymorphism in alcoholism: a family-based association study.|Association:Not Found|Conclusion:Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial. Title:Genetic polymorphisms of the promoter region of dopamine D2 receptor and dopamine transporter genes and alcoholism among four aboriginal groups and Han Chinese in Taiwan.|Association:Not Found|Conclusion:The results suggest that both the DRD2 promoter region and the DAT gene do not play a significant role in conferring vulnerability to alcoholism. | Human | SLC6A2 | 6530 | solute carrier family 6 (neurotransmitter transporter), member 2 | polymorphisms in hSLC6A2 gene are not major risk factors in increasing susceptibility to either alcohol dependence or its clinical |
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