Mouse | OSM | 5008 | oncostatin M | The putative role of OSM as an immunotherapeutic agent in human adrenocortical cancer remains to be elucidated. |
Mouse | INHA | 3623 | inhibin, alpha | Castrated inhibin alpha knockout mice develop sex steroidogenic adrenal cortical tumors. When gonadectomized, inhibin alpha/SV40 T-antigen transgenic mice develop adrenocortical tumors in a gonadotropin-dependent fashion. |
Mouse | IGFBP2 | 3485 | insulin-like growth factor binding protein 2, 36kDa | Additionally, it has been shown that overexpression of IGFBP-2 can promote malignant transformation of Y1 mouse adrenocortical tumor cells through unknown IGF-independent mechanisms. |
Mouse | GATA6 | 2627 | GATA binding protein 6 | In striking contrast to this, GATA-6 was absent from murine adrenocortical tumors, while GATA-4 mRNA expression was dramatically upregulated in the murine adrenal tumors as well as in human adrenocortical carcinomas. GATA-6 has been shown to be downregulated in mouse adrenocortical tumors, but has not been studied in human adrenocortical tumors in detail. GATA-4 is highly expressed in the adrenocortical tumors of gonadectomized mice, whereas GATA-6 is down-regulated in the tumor area. |
Mouse | GATA4 | 2626 | GATA binding protein 4 | Click here to display 6 evidence detail records. |
Mouse | DUSP1 | 1843 | dual specificity phosphatase 1 | To determine whether MKP-1 is a component of ACTH cascade, here we investigate the expression levels of MKP-1 gene in Y1 mouse adrenocortical tumor cells under ACTH stimulation. |
Mouse | CYP21A2 | 1589 | cytochrome P450, family 21, subfamily A, polypeptide 2 | Click here to display 5 evidence detail records. |
Mouse | CYP11A1 | 1583 | cytochrome P450, family 11, subfamily A, polypeptide 1 | We have previously identified a transcriptional enhancer in the 5;-flanking sequence [-183 to -83 base pairs (bp)] of the bovine CYP11A gene, which activates transcription of a beta-globin promoter/reporter gene in transiently transfected mouse Y1 adrenocortical tumor cells in response to the activator of adenylate cyclase, forskolin. The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells. Salt-inducible kinase (SIK), expressed in Y1 mouse adrenocortical tumor cells at an early stage of adrenocorticotropic hormone (ACTH)-stimulation, represses the cAMP-responsive element (CRE)-dependent gene expression of CYP11A and StAR by acting on bZIP domain of CRE-binding protein. |
Mouse | AKT1 | 207 | v-akt murine thymoma viral oncogene homolog 1 | The inverse correlation between levels of phosphorylated Akt/PKB and of p27(Kip1) protein caused by ACTH suggests a novel antimitogenic pathway activated by ACTH and mediated by cAMP/PKA in the mouse Y1 adrenocortical tumor cell line. ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation. |
Mouse | NR0B1 | 190 | nuclear receptor subfamily 0, group B, member 1 | Here we show that DAX-1 blocks steroid production at multiple levels in the Y-1 mouse adrenocortical tumor cell line. |
Mouse | ADRB2 | 154 | adrenoceptor beta 2, surface | A mouse beta 2-adrenergic receptor (beta 2AR) DNA clone was transfected and expressed in a mouse adrenocortical tumor cell line (Kin8) that lacks both beta 2AR and cAMP-dependent protein kinase (PKA). |
Human | H19 | 283120 | H19, imprinted maternally expressed transcript (non-protein coding) | Association of H19 promoter methylation with the expression of H19 gene in adrenocortical tumors |
Human | UCN3 | 114131 | urocortin 3 | INFERRED, Score=800, UMLKSK CUI: C0001618 |
Human | INHBE | 83729 | inhibin, beta E | Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice. |
Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumors. |
Human | DCUN1D1 | 54165 | DCN1, defective in cullin neddylation 1, domain containing 1 | INFERRED, Score=800, UMLKSK CUI: C0001618 |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Acylated and unacylated ghrelin are potential auto/paracrine factors acting through an antiapoptotic pathway to stimulate adrenocortical tumor cell growth |
Human | NES | 10763 | nestin | Nestin expression in normal adrenal gland and adrenocortical tumors. |
Human | MSLN | 10232 | mesothelin | INFERRED, Score=800, UMLKSK CUI: C0001618 |
Human | NCOR2 | 9612 | nuclear receptor corepressor 2 | INFERRED, Score=800, UMLKSK CUI: C0001618 |
Human | NCOR1 | 9611 | nuclear receptor corepressor 1 | INFERRED, Score=800, UMLKSK CUI: C0001618 |
Human | NCOA1 | 8648 | nuclear receptor coactivator 1 | Finally, we demonstrate that the coactivators CBP and SRC-1 are limiting with respect to cAMP-induced CRS2-dependent transcription in Y1 adrenocortical tumor cells, suggesting that part of the action of cAMP may be to influence the interaction of SF-1 with other cofactors via the AF-2 domain. |
Human | WT2 | 7491 | Wilms tumor 2 | INFERRED, Score=800, UMLKSK CUI: C0001618 |
Human | VIPR1 | 7433 | vasoactive intestinal peptide receptor 1 | Vasoactive intestinal peptide (VIP) stimulates cortisol secretion from the H295 human adrenocortical tumour cell line via VPAC1 receptors. |
Human | UROD | 7389 | uroporphyrinogen decarboxylase | INFERRED, Score=800, UMLKSK CUI: C0001618 |