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Genes (13)
Species: human : 13 | |
Human | THBD | 7056 | thrombomodulin | Title:Polymorphisms in various coagulation genes in black South African women with placental abruption.|Association:Not Found|Conclusion:The Factor V Leiden and prothrombin variant gene alleles were not detected in either patient or control groups. The thrombomodulin polymorphic variant was not seen in the patient group but three heterozygotes (1%) were found in the controls. No homozygotes for the MTHFR T677 variant were detected in the patients but two (1%) were noted in the controls; the normal and heterozygote genotype and allele frequencies for this polymorphism were similar in the two groups. | Human | SLC19A1 | 6573 | solute carrier family 19 (folate transporter), member 1 | The RFC-1 c.80A-->G polymorphism is less biologically significant for placental abruption | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | The Glu298Asp variant of eNOS is associated with an increased risk for abruptio placentae in pre-eclampsia Title:The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption.|Association:Y|Conclusion:We conclude that the presence of the Glu298Asp eNOS gene variant could be a marker of increased risk of developing placental abruption. | Human | MTRR | 4552 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | Distributions for the homozygous mutant form of MTRR were similar between cases and controls, polymorphisim did not increase the risk of placental abruption | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | A FV Leiden/ methylenetetrahydrofolate reductase (MTHFR) T677T double genotype increases the risk for placental abruption MTHFR C677T polymorphism does not have a major role in the development of preeclampsia or placental abruption in the Finnish population in Black South African population, frequency of MTHFR 677 C-T polymorphism did not differ between patients with abruptio placentae and controls Title:Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placentae but not with intrauterine growth restriction.|Association:Y|Conclusion:Combined heterozygosity for MTHFR mutations C677T and A1298C may represent a genetic marker for abruptio placentae. We found a non-significant increased risk of being a homozygous MTHFR C677T carrier in the placental abruption group In this population, neither heterozygosity nor homozygosity for the 677C-->T and 1298A-->C variants in MTHFR was associated with placental abruption Title:MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae.|Association:Not Found|Conclusion:We conclude that women who are 'QQ' homozygote for the MTHFD1 1258G --> A (R653Q) polymorphism are almost three times more likely to develop severe abruptio placentae during their pregnancy than women who are 'RQ' or 'RR.' | Human | MTHFD1 | 4522 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | Title:MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae.|Association:Y|Conclusion:We conclude that women who are 'QQ' homozygote for the MTHFD1 1258G --> A (R653Q) polymorphism are almost three times more likely to develop severe abruptio placentae during their pregnancy than women who are 'RQ' or 'RR.' Results conclude that women who are 'QQ' homozygote for the MTHFD1 1258G --> A (R653Q) polymorphism are almost three times more likely to develop severe abruptio placentae during their pregnancy than women who are 'RQ' or 'RR.' | Human | MT3 | 4504 | metallothionein 3 | metallothionein in decidual cells seems to be responsible for the proper coexistence between decidual cells and activated immune cells that infiltrate both eutopic and ectopic decidua during cesarean section and placental abruption | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | no significant difference in IL1Ra polymorphisms between patients with and without placental abruption | Human | F5 | 2153 | coagulation factor V (proaccelerin, labile factor) | The M385T variant in the factor V gene other than the Leiden mutation may play a role in susceptibility to placental abruption A FV Leiden/methylenetetrahydrofolate reductase (MTHFR )T677T double genotype increases the risk for placental abruption We found that factor V Leiden is a significant risk factor for placental abruption | Human | F3 | 2152 | coagulation factor III (thromboplastin, tissue factor) | levels of tissue factor in placenta and myometrium, over tissue factor in blood plasma may be clinically significant in obstetrics, for instance, in the etiology of DIC in placental abruption | Human | EPHX1 | 2052 | epoxide hydrolase 1, microsomal (xenobiotic) | Title:Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption.|Association:Not Found|Conclusion:The use of two intragenic SNPs jointly in haplotype analysis of association demonstrated that the genetically determined low-activity haplotype C-A (His113-His139) was significantly less frequent in women with placental abruption. | Human | BHMT | 635 | betaine--homocysteine S-methyltransferase | association between the homozygous mutant form of BHMT (742G-->A) polymorphism and increased risk for placental abruption | Human | AGT | 183 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | AGT Thr235 mutation may be considered a risk factor for placental abruption |
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