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Genes (41)
Species: human : 41 | |
Human | H19 | 283120 | H19, imprinted maternally expressed transcript (non-protein coding) | there were no differences in the genotype and allele distribution of H19 polymorphism frequencies between females with idiopathic recurrent spontaneous abortion and controls | Human | SYCP3 | 50511 | synaptonemal complex protein 3 | mutations in SYPR3 are likely to generate an aberrant synaptonemal complex in a dominant-negative manner and contribute to abnormal chromosomal behavior that might lead to recurrent miscarriage | Human | PROCR | 10544 | protein C receptor, endothelial | The EPCR A1 haplotype reduced the risk for recurrent miscarriage in carriers of FV Leiden mutations in the EPCR are not a major cause of recurrent miscarriage although they may exert a modifier effect in combination with other variants | Human | VEGFA | 7422 | vascular endothelial growth factor A | the -1154G/A VEGF gene polymorphism is associated with idiopathic recurrent abortions | Human | TYMS | 7298 | thymidylate synthetase | TS polymorphism may be a genetic determinant of plasma homocysteine level in Korean patients with recurrent spontaneous abortion | Human | TP53 | 7157 | tumor protein p53 | an over-representation of the Pro allele of the p53 gene in women with idiopathic recurrent miscarriage gives support to the theory that p53 has a potential role during pregnancy | Human | TNF | 7124 | tumor necrosis factor | INFERRED, Score=800, UMLKSK CUI: C0000809 | Human | THBD | 7056 | thrombomodulin | mutations in the TM are not a major cause of recurrent miscarriage although they may exert a modifier effect in combination with other variants | Human | TGFB2 | 7042 | transforming growth factor, beta 2 | The endometria from women with idiopathic infertility TGFbeta2 expression was 2.8 fold higher than in endometria from control group and 2.1 fold higher in endometrial samples from women with unexplained recurrent miscarriage compared to the control group | Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | while platelet microparticles were higher, CD62P (selectin P) levels were not significantly higher in the women with recurrent spontaneous abortion compared with the control group | Human | SELL | 6402 | selectin L | Importance of CD62L expression on lymphocytes for recurrent miscarriage and the relevance of the maternal response to microbial antigens during pregnancy should be further explored | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | homozygosity for the ACE D allele is a risk factor for recurrent spontaneous miscarriages(RM); homozygosity for the ACE D and PAI-1 4G alleles additionally amplifies the RM risk; this may be exerted by their common effect to increase PAI-1 expression | Human | PAEP | 5047 | progestagen-associated endometrial protein | Peri-implantation levels of glycodelin are lower in women with a history of recurrent miscarriage | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | The vasoconstrictively acting genotype NOS3 4/4 is of similar prevalence in recurrent spontaneous abortions patients and in controls there was no influence of the two polymorphisms, VNTR in intron 4 and Glu298Asp of the eNOS (endothelial nitric oxide synthase) gene on recurrent abortion in early pregnancy data fall short of showing significant association between a variant of the promoter of interleukin-1beta, polymorphism of angiotensinogen, and the missense variant of endothelial nitric oxide synthase and occurrence of idiopathic recurrent miscarriage | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The authors did not find any significant role of factor V Leiden Hong Kong/Cambridge mutation and MTHFR polymorphism in the development of recurrent abortion Hyperhomocysteinemia, a risk factor for thrombosis, recurrent miscarriages, and osteoporosis, might derive from acquired folate and vitamin B 12 deficiencies and from a C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) gene MTHFR gene might be the key thrombophilia gene conferring susceptibility to recurrent spontaneous abortion in Chinese women The mutations of methylenetetrahydrofolate reductase C677T and A1298C play a role in the mechanism of unexplained recurrent spontaneous abortion Carriage of the mutant allele of the MTHFR C677T polymorphism is associated with elevated serum levels of homocysteine and idiopathic recurrent miscarriage | Human | KIR2DL2 | 3803 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 | increased frequency in recurrent spontaneous abortion group | Human | KIR2DL1 | 3802 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 | A significant decrease in NK cell CD158a expression was demonstrated in recurrent spontaneous abortion women | Human | INHA | 3623 | inhibin, alpha | The lower expression of follistatin and beta A subunit in women with recurrent miscarriage may imply an altered activity of activin A at the time of decidualization, which may lead to poor pregnancy outcome in the form of miscarriage findings suggest that inhibin A is a specific marker of early pregnancy loss before the onset of the clinical symptoms of recurrent miscarriage | Human | IL8 | 3576 | interleukin 8 | Cervical IL-6 and IL-8 might have predictive value for cases of recurrent miscarriage | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | Although known to alter IL-6 expression, the IL-6 polymorphism investigated was not associated with idiopathic recurrent miscarriage and alterations in IL-6 serum levels in a Middle-European Caucasian population | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | women with recurrent spontaneous abortion showed a significantly increased frequency of genotypes bearing the rare allele IL1RN*3 Variation in the IL-1 receptor antagonist gene and IL-1 beta genes individually does not play a role in susceptibility to recurrent miscarriage | Human | IL1B | 3553 | interleukin 1, beta | Variation in the IL-1 beta gene and IL-1 receptor antagonist gene individually does not play a role in susceptibility to recurrent miscarriage.and genes individually does not play a role in susceptibility to recurrent miscarriage data fall short of showing significant association between a variant of the promoter of interleukin-1beta, polymorphism of angiotensinogen, and the missense variant of endothelial nitric oxide synthase and occurrence of idiopathic recurrent miscarriage | Human | IGF2 | 3481 | insulin-like growth factor 2 (somatomedin A) | The presence of IGF-2 ApaI polymorphism in partners of recurrent spontaneous abortion (RSA) women could affect IGF-2 level of expression in placenta and embryo and represent a risk factor for RSA susceptibility | Human | HLA-G | 3135 | | The HLA-G genotype, homozygous for the presence of the 14 bp sequence in exon 8, was significantly associated with reduced fertility with respect to unsuccessful IVF treatments and increased risk of recurrent miscarriage a greater number of 14-bp insertion alleles exist in the recurrent spontaneous abortion group than in the controls 14-bp deletion of the HLA-G gene is increased in the recurrent spontaneous abortion women HLA-G polymorphisms do not modify the risk of recurrent spontaneous abortion in the Polish population HLA-G polymorphisms in couples with recurrent spontaneous abortions | Human | HLA-DRB1 | 3123 | | HLA-DRB1*1502 might be a risk allele for unexplained recurrent abortion in the Japanese population |
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