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Details
Link-It Detail - Anatomy - Anti-mesothelin CIR mRNA-electroporated Autologous T Cells
Debug Stats
  • ### Total Build Time: 12 ms 5.869 KB
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Anatomy (1)
Anti-mesothelin CIR mRNA-electroporated Autologous T Cells C3273206
Definition (1)
Autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin chimeric T cell receptor mRNA, with potential antineoplastic activity. The anti-mesothelin mRNA encodes a single chain antibody variable fragment (ScFv), the intracellular CD 3 zeta T cell receptor domain and the 4-1BB (cd137) costimulatory domain. Upon intravenous administration, the anti-mesothelin CIR mRNA-electroporated autologous T cells may attach to cancer cells expressing mesothelin. This may stimulate the secretion of multiple cytokines and may result in cell lysis of mesothelin-expressing cancer cells. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers.
Relationships (4)

Relation Types:
anat_​to_​anat : 1
anat_​to_​phys : 1
chem_​to_​anat : 1
chem_​to_​phys : 1


Relationships:
cell_​type_​or_​tissue_​affected_​by_​chemical_​or_​drug : 2
is_​mechanism_​of_​action_​of_​chemical_​or_​drug : 2
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
ANAT_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
CHEM_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
CHEM_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C3273206Anti-mesothelin CIR mRNA-electroporated Autologous T Cells0self