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Details
Link-It Detail - Anatomy - Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells
Debug Stats
  • ### Total Build Time: 18 ms 5.069 KB
  • CONCEPT_NAME gt=13 ms Completed: 13 ms rowSize= 420 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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Anatomy (1)
Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells C2981629
Definition (1)
A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment); an extracellular portion of human CD28 and the entire transmembrane and cytoplasmic portion of human CD28; and the cytoplasmic portion of the human TCR-[zeta] molecule with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR retroviral vector-transduced autologous T cells may stimulate host cytotoxic T lymphocyte (CTL) and antibody responses against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the T-cell receptor (TCR)/CD3 complex and regulates the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development.
Relationships (2)

Relation Types:
anat_​to_​anat : 1
anat_​to_​phys : 1


Relationships:
cell_​type_​or_​tissue_​affected_​by_​chemical_​or_​drug : 1
is_​mechanism_​of_​action_​of_​chemical_​or_​drug : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
ANAT_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C2981629Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells0self