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Details
Link-It Detail - Anatomy - 2G-1 TCR Retroviral Vector-Transduced Lymphocytes
Debug Stats
  • ### Total Build Time: 25 ms 6.063 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 396 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
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  • Reload Stats
Anatomy (1)
2G-1 TCR Retroviral Vector-Transduced Lymphocytes C2826155
Definition (1)
A preparation of autologous human T-lymphocytes isolated from renal cell cancer (RCC) patient and transduced with 2G-1 TCR, a retroviral vector encoding the alpha and beta chains of a T-cell receptor that recognizes TNF-related apoptosis inducing ligand (TRAIL) bound to death receptor 4 (DR4), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and introduction into the RCC patient, 2G-1 TCR retroviral vector-transduced lymphocytes may stimulate a cytotoxic T lymphocyte (CTL) response against RCC cells with TRAIL bound to DR4 on their surfaces. TRAIL, a member of the TNF superfamily, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells when bound to its receptors; DR4 (TRAIL receptor 1), a member of the TNF receptor family, is overexpressed by a variety of malignant cell types.
Relationships (4)

Relation Types:
anat_​to_​anat : 1
anat_​to_​phys : 1
chem_​to_​anat : 1
chem_​to_​phys : 1


Relationships:
cell_​type_​or_​tissue_​affected_​by_​chemical_​or_​drug : 2
is_​mechanism_​of_​action_​of_​chemical_​or_​drug : 2
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
ANAT_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
CHEM_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
CHEM_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C28261552G-1 TCR Retroviral Vector-Transduced Lymphocytes0self