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Details
Link-It Detail - Anatomy - 19S Proteasome Regulatory Particle
Debug Stats
  • ### Total Build Time: 5 ms 4.733 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 366 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 670 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 2.439 KB
  • CONCEPT_GENES gt=3 ms Completed: 3 ms rowSize= 45 bytes
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.168 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Anatomy (1)
19S Proteasome Regulatory Particle C1518774
Definition (1)
Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules. The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides. Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain. A protein complex containing p42 and p50 enhances PA700 activation of the proteasome.
Relationships (3)

Relation Types:
anat_​to_​anat : 1
anat_​to_​chem : 2


Relationships:
gene_​product_​has_​associated_​anatomy : 1
has_​physical_​part_​of_​anatomic_​structure : 2
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANAThas_physical_part_of_anatomic_structureimg Cells C0007634
ANAT_to_CHEMhas_physical_part_of_anatomic_structureimg 26S proteasome C0286330
ANAT_to_CHEMgene_product_has_associated_anatomyimg Probable E3 Ubiquitin-Protein Ligase TRIP12 C2984125
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C151877419S Proteasome Regulatory Particle0self