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Details
Link-It Detail - Anatomy - Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL
Debug Stats
  • ### Total Build Time: 7 ms 5.127 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 414 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 572 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=3 ms Completed: 3 ms rowSize= 2.858 KB
  • CONCEPT_GENES gt=1 ms Completed: 1 ms rowSize= 45 bytes
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.191 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Anatomy (1)
Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL C1515996
Definition (1)
Human peripheral blood lymphocytes (PBL) isolated from a melanoma patient and were engineered to react with the melanoma antigen glycoprotein 100 (gp100). These PBL are transduced with a retroviral pGCsam vector encoding T-cell receptors specific for gp100, grown in culture, and then transferred back to the patient. These genetically modified PBL may recognize and halt the growth of gp100-expressing melanoma cells.
Relationships (3)

Relation Types:
anat_​to_​anat : 1
anat_​to_​chem : 1
anat_​to_​phys : 1


Relationships:
cell_​type_​or_​tissue_​affected_​by_​chemical_​or_​drug : 1
is_​mechanism_​of_​action_​of_​chemical_​or_​drug : 1
is_​target : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
ANAT_to_CHEMis_targetimg gp100 Antigen C0281722
ANAT_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1515996Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL0self