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Details
Link-It Detail - Anatomy - 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
Debug Stats
  • ### Total Build Time: 8 ms 5.889 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 420 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 914 bytes
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  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
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  • Reload Stats
Anatomy (1)
1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex C1167410
Definition (1)
A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. [PMID:9255069, PMID:9759495]
Parents (1)
img 1-phosphatidylinositol 3-kinase complex C1166803
Ancestral Roots
RootRoot Plus OneDepthParent
img intracellular part C1820033img cytoplasm component C18200505img 1-phosphatidylinositol 3-kinase complex C1166803
Relationships (1)

Relation Types:
anat_​to_​anat : 1


Relationships:
mth_​expanded_​form_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATmth_expanded_form_ofimg 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex C1167410
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C11674101-phosphatidylinositol-4-phosphate 3-kinase, class IA complex0self