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Details
Link-It Detail - Anatomy - therapeutic autologous dendritic cells
Debug Stats
  • ### Total Build Time: 15 ms 9 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 374 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.194 KB
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Anatomy (1)
therapeutic autologous dendritic cells C0879593
Definition (1)
A population of a type of antigen-presenting cell (APC), the dendritic cell (DC), harvested from a patient and grown in vitro in the presence of tumor-associated antigens (TAAs) derived from the patient's tumor (a technique known as 'pulsing') and then injected back into the patient; autologous DCs so manipulated may stimulate a specific cell-mediated antitumoral cytotoxicity. DCs derived from a patient may also be fused with the patient's tumor cells in vitro to combine sustained tumor antigen expression with the antigen-presenting and immunostimulatory capacities of DCs; when injected back into the patient, these autologous DC-tumor cell hybrids (fusion cells) may stimulate an active antitumoral immune response. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38048&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38048&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2594" NCI Thesaurus)
Relationships (10)

Relation Types:
anat_​to_​anat : 2
anat_​to_​chem : 2
anat_​to_​phys : 1
chem_​to_​anat : 2
chem_​to_​chem : 2
chem_​to_​phys : 1


Relationships:
cell_​type_​or_​tissue_​affected_​by_​chemical_​or_​drug : 2
is_​mechanism_​of_​action_​of_​chemical_​or_​drug : 2
isa : 6
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATisaimg CEA RNA-pulsed Autologous Human Cultured Dendritic Cells C1511434
ANAT_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
ANAT_to_CHEMisaimg Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells C2347347
ANAT_to_CHEMisaimg Autologous CD133-Positive BTSC mRNA-Pulsed Autologous Dendritic Cell Vaccine C2827668
ANAT_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
CHEM_to_ANATisaimg CEA RNA-pulsed Autologous Human Cultured Dendritic Cells C1511434
CHEM_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
CHEM_to_CHEMisaimg Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells C2347347
CHEM_to_CHEMisaimg Autologous CD133-Positive BTSC mRNA-Pulsed Autologous Dendritic Cell Vaccine C2827668
CHEM_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0879593therapeutic autologous dendritic cells0self